Francisco Comesana

In May 2022, Comesaña won his first ATP Challenger doubles title in Vicenza, partnering Luciano Darderi. The following month, he won back-to-back singles titles at the Corrientes Challenger and the Challenger Tenis Club Argentino, both in his home country and both against Mariano Navone in the final.

In May 2023, he reached the final of the Macedonian Open, but lost to Máté Valkusz. The following week, he won the Internazionali di Tennis Città di Vicenza, defeating Pablo Llamas Ruiz in the final. Later that year, he won his fourth Challenger title at the Svijany Open and reached the final of the Santa Cruz Challenger.

In February 2024, Comesaña made his ATP debut at the Córdoba Open as a wildcard, but lost to compatriot and lucky loser Thiago Agustín Tirante in the first round. He qualified for his first ATP 500 tournament at the Rio Open, but lost to fourth seed and compatriot Francisco Cerúndolo in the first round. He entered the Chile Open as a lucky loser, but lost to Juan Pablo Varillas in the first round.

After winning the Open de Oeiras in April, he reached the top 100 for the first time.

Ranked No. 122, he made his Grand Slam debut at Wimbledon and upset sixth seed Andrey Rublev in the first round in only his second match on grass ever. This was his first win at the ATP level, his first win at a Major, and his first win over a top 10 player. He then defeated Adam Walton to reach the third round. He lost to eventual semifinalist Lorenzo Musetti in four sets.

On his debut at the US Open, he reached again the third round of a Grand Slam, defeating Dominic Stricker in the first round, then upsetting 17th-seed Ugo Humbert in the second round.