Home History
| Anglia - Premier League 2 | 2021/09/10 18:00 | Fulham - U23 v Southampton - U23 | L | 3-0 |
| Angol Premier League Cup - U23 | 2021/09/02 18:00 | Arsenal - U23 v Southampton - U23 | D | 1-1 |
| Anglia - Premier League 2 | 2021/08/29 11:00 | Middlesbrough - U23 v Southampton - U23 | L | 2-1 |
| Anglia - Premier League 2 | 2021/08/23 18:00 | Nottm Forest - U23 v Southampton - U23 | D | 0-0 |
| Anglia - Premier League 2 | 2021/08/15 13:00 | Southampton - U23 v Norwich - U23 | L | 0-3 |
| Anglia - Premier League 2 | 2021/05/07 18:00 | Everton - U23 v Southampton - U23 | L | 4-0 |
| Anglia - Premier League 2 | 2021/05/02 13:00 | Southampton - U23 v Everton - U23 | L | 0-5 |
| Anglia - Premier League 2 | 2021/04/19 18:00 | Leicester - U23 v Southampton - U23 | L | 7-1 |
Away History
| Anglia - Premier League 2 | 2021/09/10 18:00 | Burnley - U23 v Wolverhampton - U23 | D | 1-1 |
| Anglia - Premier League 2 | 2021/08/27 18:00 | Newcastle - U23 v Burnley - U23 | L | 2-0 |
| Anglia - Premier League 2 | 2021/08/23 18:00 | Burnley - U23 v Sunderland - U23 | L | 2-3 |
| Anglia - Premier League 2 | 2021/08/16 18:00 | West Brom - U23 v Burnley - U23 | L | 3-2 |
| Anglia - Premier League 2 | 2021/05/03 12:00 | Leeds - U23 v Burnley - U23 | L | 5-2 |
| Anglia - Premier League 2 | 2021/04/16 12:00 | Reading - U23 v Burnley - U23 | W | 0-2 |
| Anglia - Premier League 2 | 2021/04/12 13:00 | Burnley - U23 v Norwich - U23 | D | 2-2 |
| Anglia - Premier League 2 | 2021/03/29 12:00 | Sunderland - U23 v Burnley - U23 | L | 3-0 |