[83] Middle Tennessee 13-27 Texas San Antonio [18] 2021-09-18 22:00
Stadium: Alamodome Round: 1
Home Manager: Jeff Traylor Away Manager: Rick Stockstill
Head to Head
| NCAAF | 2020/09/26 00:00 | Middle Tennessee St. v Texas-San Antonio | L | 35-37 |
| NCAAF | 2016/11/05 18:30 | Texas-San Antonio v Middle Tennessee St. | L | 45-25 |
| NCAAF | 2015/11/28 19:30 | Texas-San Antonio v Middle Tennessee St. | W | 7-42 |
Home History
| NCAAF | 2021/09/11 18:00 | Middle Tennessee St. v Virginia Tech | L | 14-35 |
| NCAAF | 2021/09/04 23:00 | Monmouth v Middle Tennessee St. | W | 15-50 |
| NCAAF | 2020/11/21 20:30 | Middle Tennessee St. v Troy | W | 20-17 |
| NCAAF | 2020/11/14 17:00 | Middle Tennessee St. v Marshall | L | 14-42 |
| NCAAF | 2020/10/24 19:30 | Middle Tennessee St. v Rice | W | 40-34 |
| NCAAF | 2020/10/17 21:00 | North Texas v Middle Tennessee St. | L | 52-35 |
| NCAAF | 2020/10/10 20:00 | Middle Tennessee St. v Florida Intl | W | 31-28 |
| NCAAF | 2020/10/03 21:00 | Western Kentucky v Middle Tennessee St. | L | 20-17 |
Away History
| NCAAF | 2021/09/11 22:00 | Lamar v Texas-San Antonio | W | 0-54 |
| NCAAF | 2021/09/04 23:30 | Texas-San Antonio v Illinois | W | 37-30 |
| NCAAF | 2020/12/26 20:30 | Lafayette v Texas-San Antonio | L | 31-24 |
| NCAAF | 2020/11/28 20:00 | North Texas v Texas-San Antonio | W | 17-49 |
| NCAAF | 2020/11/21 20:00 | Texas-San Antonio v Southern Mississippi | W | 23-20 |
| NCAAF | 2020/11/14 20:00 | UTEP v Texas-San Antonio | W | 21-52 |
| NCAAF | 2020/10/31 16:00 | Texas-San Antonio v Florida Atlantic | L | 3-24 |
| NCAAF | 2020/10/25 00:00 | Louisiana Tech v Texas-San Antonio | W | 26-27 |