[6] Defensor Sporting 0-1 Nacional De Football [5] 2022-06-13 22:30
Stadium: Estadio Luis Franzini Round: 1
Referee: Andres Ismael Cunha Soca Home Manager: Marcelo Fabian Mendez Russo Away Manager: Pablo Repetto
Head to Head
| Uruguayi Apertura | 2022/05/14 21:00 | Defensor Sporting v Nacional De Football | L | 0-2 |
| Uruguayi Clausura | 2021/03/08 00:45 | Nacional De Football v Defensor Sporting | L | 2-1 |
| Uruguayi Torneo Intermedio | 2020/11/07 21:00 | Nacional De Football v Defensor Sporting | L | 3-0 |
| Uruguayi Apertura | 2020/09/10 23:15 | Defensor Sporting v Nacional De Football | D | 1-1 |
| Uruguayi Clausura | 2019/11/21 23:30 | Defensor Sporting v Nacional De Football | W | 2-1 |
| Uruguayi Torneo Intermedio | 2019/07/13 21:00 | Nacional De Football v Defensor Sporting | W | 1-2 |
| Uruguayi Apertura | 2019/05/19 21:30 | Nacional De Football v Defensor Sporting | L | 1-0 |
| Uruguayi Clausura | 2018/08/26 21:30 | Defensor Sporting v Nacional De Football | W | 2-0 |
Home History
| Uruguayi Apertura | 2022/06/05 15:00 | Rentistas v Defensor Sporting | L | 1-0 |
| Uruguayi Apertura | 2022/05/29 20:30 | Defensor Sporting v Deportivo Maldonado | D | 1-1 |
| Uruguayi Apertura | 2022/05/22 18:30 | Danubio v Defensor Sporting | W | 1-2 |
| Uruguayi Apertura | 2022/05/14 21:00 | Defensor Sporting v Nacional De Football | L | 0-2 |
| Uruguayi Apertura | 2022/05/07 16:00 | Albion FC v Defensor Sporting | W | 0-3 |
| Uruguayi Apertura | 2022/04/25 23:00 | Defensor Sporting v Cerrito | D | 0-0 |
| Uruguayi Apertura | 2022/04/15 23:15 | Defensor Sporting v Atletico Fenix Montevideo | W | 2-1 |
| Uruguayi Apertura | 2022/04/08 22:15 | Cerro Largo v Defensor Sporting | D | 0-0 |
Away History
| Uruguayi Apertura | 2022/06/05 18:00 | Danubio v Nacional De Football | L | 2-1 |
| Uruguayi Apertura | 2022/05/28 23:00 | Nacional De Football v Cerrito | W | 3-0 |
| Copa Libertadores | 2022/05/24 22:15 | Nacional De Football v Bragantino | W | 3-0 |
| Uruguayi Apertura | 2022/05/21 20:00 | Nacional De Football v Albion FC | W | 2-0 |
| Copa Libertadores | 2022/05/18 22:00 | Nacional De Football v Velez Sarsfield | L | 2-3 |
| Uruguayi Apertura | 2022/05/14 21:00 | Defensor Sporting v Nacional De Football | W | 0-2 |
| Uruguayi Apertura | 2022/05/09 22:30 | Nacional De Football v Atletico Fenix Montevideo | W | 1-0 |
| Copa Libertadores | 2022/05/04 00:30 | Estudiantes LP v Nacional De Football | L | 1-0 |