[14] UL Lafayette 24-39 Southern Miss [9] 2022-10-27 23:30
Stadium: M.M. Roberts Stadium Round: 1
Home Manager: Will Hall Away Manager: Michael Desormeaux
Head to Head
| NCAAF | 2016/12/18 02:00 | Southern Mississippi v Lafayette | L | 28-21 |
| NCAAF | 2008/08/30 12:00 | Southern Mississippi v Lafayette | L | 51-21 |
| NCAAF | 2003/11/01 12:00 | Southern Mississippi v Lafayette | L | 48-3 |
| NCAAF | 2001/09/22 12:00 | Lafayette v Southern Mississippi | L | 10-35 |
Home History
| NCAAF | 2022/10/22 21:00 | Arkansas State v Lafayette | W | 18-38 |
| NCAAF | 2022/10/22 19:30 | Holy Cross v Lafayette | L | 24-21 |
| NCAAF | 2022/10/12 23:30 | Lafayette v Marshall | W | 23-13 |
| NCAAF | 2022/10/08 16:30 | Princeton v Lafayette | L | 23-2 |
| NCAAF | 2022/10/01 21:00 | South Alabama v Lafayette | L | 20-17 |
| NCAAF | 2022/10/01 19:30 | Lafayette v Bucknell | W | 24-14 |
| NCAAF | 2022/09/25 00:00 | Lafayette v UL Monroe | L | 17-21 |
| NCAAF | 2022/09/24 17:00 | Lafayette v Pennsylvania | L | 0-12 |
Away History
| NCAAF | 2022/10/22 21:00 | Southern Mississippi v Texas State | W | 20-14 |
| NCAAF | 2022/10/15 23:00 | Arkansas State v Southern Mississippi | W | 19-20 |
| NCAAF | 2022/10/08 23:00 | Southern Mississippi v Troy | L | 10-27 |
| NCAAF | 2022/09/24 23:00 | Southern Mississippi v Tulane | W | 27-24 |
| NCAAF | 2022/09/17 23:00 | Northwestern State v Southern Mississippi | W | 10-64 |
| NCAAF | 2022/09/10 16:00 | Southern Mississippi v Miami Florida | L | 7-30 |
| NCAAF | 2022/09/03 23:00 | Libertay v Southern Mississippi | L | 29-27 |
| NCAAF | 2021/11/27 20:00 | Florida Intl v Southern Mississippi | W | 17-37 |