Stadium: DakotaDome Round: 1
Home Manager: Bob Nielson Away Manager: Bobby Petrino
| NCAAF | 2021/09/26 00:00 | South Dakota v Missouri St | W | 23-31 |
| NCAAF | 2021/03/13 19:00 | Missouri St v South Dakota | W | 27-24 |
| NCAAF | 2019/10/12 19:00 | South Dakota v Missouri St | L | 45-10 |
| NCAAF | 2018/10/06 19:00 | Missouri St v South Dakota | L | 28-35 |
| NCAAF | 2022/10/29 19:00 | Western Illinois v Missouri St | W | 14-64 |
| NCAAF | 2022/10/22 21:00 | Missouri St v Northern Iowa | L | 20-41 |
| NCAAF | 2022/10/08 19:00 | SO Illinois v Missouri St | L | 38-21 |
| NCAAF | 2022/10/01 17:00 | Missouri St v North Dakota | L | 31-48 |
| NCAAF | 2022/09/24 19:00 | South Dakota State v Missouri St | L | 28-14 |
| NCAAF | 2022/09/17 23:00 | Missouri St v Arkansas | L | 27-38 |
| NCAAF | 2022/09/09 00:00 | Tennessee Martin v Missouri St | W | 30-35 |
| NCAAF | 2022/09/02 00:00 | Missouri St v Central Arkansas | W | 27-14 |
| NCAAF | 2022/10/29 18:00 | South Dakota v Youngstown State | L | 24-45 |
| NCAAF | 2022/10/22 19:00 | SO Illinois v South Dakota | W | 24-27 |
| NCAAF | 2022/10/15 19:00 | South Dakota v Illinois State | L | 10-12 |
| NCAAF | 2022/10/08 19:00 | South Dakota v South Dakota State | L | 3-28 |
| NCAAF | 2022/09/24 18:00 | North Dakota State v South Dakota | L | 34-17 |
| NCAAF | 2022/09/17 18:00 | Cal Poly v South Dakota | W | 21-38 |
| NCAAF | 2022/09/10 19:30 | South Dakota v Montana | L | 7-24 |
| NCAAF | 2022/09/03 23:00 | South Dakota v Kansas State | L | 0-34 |