[14] BUF Sabres 2-4 OTT Senators [25] 2018-11-01 23:30
Stadium: Canadian Tire Centre Round: 1
Home Manager: Guy Boucher Away Manager: Phil Housley
Head to Head
| NHL | 2018/04/04 23:30 | OTT Senators v BUF Sabres | L | 4-2 |
| NHL | 2018/03/09 00:30 | BUF Sabres v OTT Senators | W | 4-3 |
| NHL | 2018/02/16 00:30 | BUF Sabres v OTT Senators | L | 2-3 |
| NHL | 2017/12/13 00:00 | OTT Senators v BUF Sabres | W | 2-3 |
| NHL | 2017/02/15 00:30 | BUF Sabres v OTT Senators | W | 3-2 |
| NHL | 2017/02/05 00:00 | OTT Senators v BUF Sabres | W | 0-4 |
| NHL | 2016/11/30 00:30 | BUF Sabres v OTT Senators | W | 5-4 |
| NHL | 2016/11/10 00:30 | OTT Senators v BUF Sabres | L | 2-1 |
Home History
| NHL | 2018/10/30 23:00 | CAL Flames v BUF Sabres | L | 2-1 |
| NHL | 2018/10/27 23:00 | BUF Sabres v CLB Blue Jackets | L | 4-5 |
| NHL | 2018/10/25 23:00 | MON Canadiens v BUF Sabres | W | 3-4 |
| NHL | 2018/10/22 00:00 | BUF Sabres v ANA Ducks | W | 4-2 |
| NHL | 2018/10/20 19:30 | BUF Sabres v LA Kings | W | 5-1 |
| NHL | 2018/10/19 02:30 | BUF Sabres v SJ Sharks | L | 1-5 |
| NHL | 2018/10/17 02:00 | BUF Sabres v VGS Golden Knights | L | 1-4 |
| NHL | 2018/10/14 01:00 | BUF Sabres v ARZ Coyotes | W | 3-0 |
Away History
| NHL | 2018/10/31 02:00 | OTT Senators v ARZ Coyotes | L | 1-5 |
| NHL | 2018/10/29 00:00 | OTT Senators v VGS Golden Knights | L | 3-4 |
| NHL | 2018/10/27 01:00 | OTT Senators v COL Avalanche | L | 3-6 |
| NHL | 2018/10/23 23:30 | BOS Bruins v OTT Senators | L | 4-1 |
| NHL | 2018/10/20 23:00 | MON Canadiens v OTT Senators | W | 3-4 |
| NHL | 2018/10/15 23:30 | DAL Stars v OTT Senators | W | 1-4 |
| NHL | 2018/10/13 18:00 | LA Kings v OTT Senators | W | 1-5 |
| NHL | 2018/10/10 23:30 | PHI Flyers v OTT Senators | L | 7-4 |