[9] Oklahoma 27-13 Iowa State [10] 2022-10-29 16:00
Stadium: Jack Trice Stadium Round: 1
Home Manager: Matt Campbell Away Manager: Brent Venables
Head to Head
| NCAAF | 2021/11/20 17:00 | Iowa State v Oklahoma | W | 21-28 |
| NCAAF | 2020/12/19 17:00 | Oklahoma v Iowa State | W | 27-21 |
| NCAAF | 2020/10/03 23:30 | Oklahoma v Iowa State | L | 30-37 |
| NCAAF | 2019/11/10 01:00 | Iowa State v Oklahoma | W | 41-42 |
| NCAAF | 2018/09/15 16:00 | Oklahoma v Iowa State | W | 37-27 |
| NCAAF | 2017/10/07 16:00 | Iowa State v Oklahoma | L | 38-31 |
| NCAAF | 2016/11/03 23:30 | Oklahoma v Iowa State | W | 34-24 |
| NCAAF | 2015/11/08 00:00 | Oklahoma v Iowa State | W | 52-16 |
| NCAAF | 2014/11/01 16:00 | Iowa State v Oklahoma | W | 14-59 |
| NCAAF | 2012/11/03 12:00 | Iowa State v Oklahoma | W | 20-35 |
| NCAAF | 2011/11/26 12:00 | Oklahoma v Iowa State | W | 26-6 |
| NCAAF | 2010/10/16 12:00 | Oklahoma v Iowa State | W | 52-0 |
| NCAAF | 2007/10/20 12:00 | Iowa State v Oklahoma | W | 7-17 |
| NCAAF | 2006/10/14 12:00 | Oklahoma v Iowa State | W | 34-9 |
| NCAAF | 2003/10/04 12:00 | Iowa State v Oklahoma | W | 7-53 |
| NCAAF | 2002/10/19 12:00 | Oklahoma v Iowa State | W | 49-3 |