| Mexikói liga - U23 | 04/28 17:30 | 17 | [13] Santos Laguna - U23 v Atletico San Luis - U23 [3] | L | 0-3 | |
| Mexikói liga - U23 | 04/21 17:00 | 16 | [16] Santos Laguna - U23 v Pachuca - U23 [3] | W | 2-1 | |
| Mexikói liga - U23 | 04/12 15:00 | 15 | [1] Necaxa - U23 v Santos Laguna - U23 [13] | L | 2-1 | |
| Mexikói liga - U23 | 04/06 17:00 | 14 | Santos Laguna - U23 v Club America - U23 | L | 0-2 | |
| Mexikói liga - U23 | 03/31 15:00 | 13 | [7] Juarez FC - U23 v Santos Laguna - U23 [12] | L | 2-0 | |
| Mexikói liga - U23 | 03/15 23:45 | 12 | [18] Tijuana - U23 v Santos Laguna - U23 [13] | W | 1-5 | |
| Mexikói liga - U23 | 03/09 17:00 | 11 | [11] Santos Laguna - U23 v Cruz Azul - U23 [4] | D | 1-1 | |
| Mexikói liga - U23 | 03/01 15:00 | 10 | [17] Queretaro - U23 v Santos Laguna - U23 [9] | L | 5-1 | |
| Mexikói liga - U23 | 02/25 17:00 | 8 | [12] Santos Laguna - U23 v Mazatlan FC - U23 [15] | W | 3-0 | |
| Mexikói liga - U23 | 02/21 15:00 | 9 | [7] Toluca - U23 v Santos Laguna - U23 [14] | D | 0-0 | |
| Mexikói liga - U23 | 02/18 15:00 | 7 | [15] Unam Pumas - U23 v Santos Laguna - U23 [11] | L | 3-0 | |
| Mexikói liga - U23 | 02/10 17:00 | 6 | [10] Santos Laguna - U23 v Tigres UANL - U23 [3] | D | 1-1 | |
| Mexikói liga - U23 | 02/04 15:00 | 5 | [18] Atlas - U23 v Santos Laguna - U23 [8] | L | 3-2 | |
| Mexikói liga - U23 | 01/30 17:00 | 4 | [5] Santos Laguna - U23 v Puebla - U23 [14] | D | 1-1 | |
| Mexikói liga - U23 | 01/27 15:00 | 3 | Leon - U23 v Santos Laguna - U23 | W | 0-4 | |
| Mexikói liga - U23 | 01/21 17:00 | 2 | [14] Santos Laguna - U23 v Monterrey - U23 [6] | W | 2-1 | |
| Mexikói liga - U23 | 01/13 15:00 | 1 | Chivas Guadalajara - U23 v Santos Laguna - U23 | L | 3-2 | |
| Mexikói liga - U23 | 11/18 15:00 | 3 | [2] Chivas Guadalajara - U23 v Santos Laguna - U23 [7] | L | 3-1 | |
| Mexikói liga - U23 | 11/15 17:00 | 3 | [7] Santos Laguna - U23 v Chivas Guadalajara - U23 [2] | L | 2-4 | |
| Mexikói liga - U23 | 11/11 15:00 | 17 | [18] Atletico San Luis - U23 v Santos Laguna - U23 [8] | D | 2-2 | |
| Mexikói liga - U23 | 11/05 17:00 | 16 | [9] Santos Laguna - U23 v Toluca - U23 [15] | W | 2-1 | |
| Mexikói liga - U23 | 11/01 16:00 | 15 | [9] Mazatlan FC - U23 v Santos Laguna - U23 [7] | L | 2-1 | |
| Mexikói liga - U23 | 10/29 17:00 | 14 | [7] Santos Laguna - U23 v Juarez FC - U23 [8] | D | 0-0 | |
| Mexikói liga - U23 | 10/21 15:00 | 13 | [7] Club America - U23 v Santos Laguna - U23 [9] | L | 3-2 | |
| Mexikói liga - U23 | 10/14 15:00 | 4 | [14] Cruz Azul - U23 v Santos Laguna - U23 [9] | L | 4-1 | |
| Mexikói liga - U23 | 10/08 15:00 | 12 | Santos Laguna - U23 v Leon - U23 | D | 0-0 | |
| Mexikói liga - U23 | 10/04 17:00 | 11 | Santos Laguna - U23 v Tijuana - U23 | W | 5-0 | |
| Mexikói liga - U23 | 09/30 15:00 | 10 | Monterrey - U23 v Santos Laguna - U23 | W | 1-2 | |
| Mexikói liga - U23 | 09/24 17:00 | 9 | [11] Santos Laguna - U23 v Necaxa - U23 [7] | W | 5-0 | |
| Mexikói liga - U23 | 09/18 15:30 | 8 | [2] Pachuca - U23 v Santos Laguna - U23 [9] | L | 2-0 |